EndoZip™ - Automated endoscopic suturing for the treatment of obesity

A new world of widely available,
safe and effective treatment for obesity

Nitinotes is a clinical-stage company developing a revolutionary treatment for obesity.
Its flagship product, the EndoZip™, simplifies and speeds up endoscopic gastroplasty procedures, offering a widely available, minimally invasive, and effective solution for over 700 million patients with obesity class I & II for whom traditional bariatric surgery is not an option.

EndoZip™

Automated and operator-independent, minimally invasive suturing system, for safe and easy delivery of effective restrictive sutures to the stomach wall

Clinical overview

Nitinotes is conducting a series of pilot studies in various sites around the world aimed at fortifying both its clinical and economic cases
Ongoing

Health economics study

A new EU multi-center study was launched in 23. The primary objective of this study is to evaluate the efficacy and potential health improvement associated with weight loss in obese patients with T2D and/or hypertension following the EndoZip procedure and lifestyle modifications. Enrolments were completed with 38 patients who have successfully undergone the EndoZip™ procedure and are followed up for 12M.
Feb 2023
Completed

Pilot study

A multi-center (Madrid, Rome, Israel) pilot study was launched in July 2021 with 45 patients. After a 12-month follow-up period, the results show a high safety profile, short learning curve, and excellent usability for the Endozip suturing system, with patients averaging an impressive TBWL of 13.5% @ 12M.
Mar 2019
Completed

FIH study

FIH study in Spain was completed in 2019. Led by Dr. Lopez Nava, Director of the Bariatric Endoscopy Unit at HM Sanchinarro University Hospital, Madrid. The study included 11 patients and showed great results of 16.2% TBWL after a 6-month follow-up period.
Expert physicians share their experiences with EndoZip

“With EndoZip™, you are able to easily reproduce the same reliable suture with no additional effort”

Dr. Ivo Boškoski

“Inspect, position it, apply suction and press the button. That’s it! It's that simple"

Dr. Manoel Galvao Neto

"The suturing automation is really impresive. Everything applies the precise strength for suturing or cinching."

Dr. Gontrand López-Nava

"It's not so much expert-dependent like other ESG systems"

Dr. Evzen Machytka

"You can’t do anything wrong with the device or make any significant mistake"

Dr. Jan Kral

"While other systems require at least 20 cases to become proficient, with EndoZip™, it took only 3..."

Dr. Steven Shamah

“The stomach reduction we achieve after the procedure is fantastic”

Dr. Roman Turro

The features and benefits of automated gastroplasty

Simple. Accessible. Scalable
Consistent suture size
and depth in each pass
High suture density
& durability
Reproducible
results
Improved offering
for patients and physicians
Easy to learn
at any skill level
Single
operator
Shorter
procedure time
Improved accessibility
and economics

About us

Nitinotes is a clinical-stage medical device company based in Caesarea, Israel. Its flagship product EndoZip™, is a novel automated endoscopic suturing system for safer and simpler gastroscopic restriction for the treatment of obesity.

Backed by clinical success and prominent KOLs, Nitinotes’s fully automated, minimally invasive gastroscopic suturing system provides an effective solution for 85% of the obese population (class 1 and 2 obesity) who do not qualify for bariatric surgery.

Management team

Raz Bar-On

BSc, MBA
CEO

Sergio Levi

BSc, MBA
CBO

Hagit Ephrath

MA
COO & Regulatory Affairs

Tal Yered

BSc, MSc
VP R&D & Engineering

Board of directors

John Barr

Chair of the board

Dr. Christoph Kausch

Director

Dr. Anne Mathieu

Director

Dr. Irit Yaniv

Director

Lior Lugassy

Director

Raz Bar-On

Director & CEO

Scientific advisory board

Barham Abu Dayyeh

MD MPH FASGE FAGA
Director of Advance Endoscopy, Director of Metabolic and Bariatric Endoscopy, Professor of Medicine, Vice-Chair of Innovation, Mayo Clinic, Rochester, MN

Ivo Boškoski

MD, PhD, FESGE
Assistant Professor of Gastroenterology (RTDB), Università Cattolica del Sacro Cuore - Gastroenterology & Digestive Endoscopy at Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Gontrand López-Nava

MD, PhD, FASGE
Director of Bariatric Endoscopy at Madrid Sanchinarro University Hospital

Manoel Galvao Neto

MD, MSC, FASGE, IFASBMS
Head of Bariatric Endoscopy of Mohak Bariatric and Robotics, Scientific Director at Endovitta Institute, Head of Bariatric Endoscopy at EOC

Shelby Sullivan

MD, FACG, FABOM
Associate Professor at University of Colorado School of Medicine Director of the Gastroenterology Metabolic and Bariatric Program

Reem Sharaiha

MD, MSc
Director of Therapeutic and Advanced Endoscopy, Hospital-Weill Cornell Medical Center

Steven Shamah

MD
Faculty Member at Rabin Medical Center

Roman Turro

MD
Director of Bariatric, Metabolic and Digestive Endoscopy at Centro Medico Teknon Barcelona , national coordinator bariatric endoscopy group (Gettemo) at the national endoscopy society SEED

Christine Stier

MD , PhD
Associate professor of Interdisciplinary Endoscopy
Department, University Hospital Mannheim, Germany.
Chair Member of the German Working Group on Metabolic
Endoscopy, Chair of the Bariatric Endoscopy Committee
of the World Association IFSO, and Chair Member of the
German Obesity Alliance (DAA).

Our investors

Contact Us

Nitinotes Ltd.
5 Haeshel st, Beit Galileo 2,
P.O Box 3158, Caesarea, 3079815, Israel
Tel. +972.4.8876698
info@nitinotesurgical.com